BioIntelligence/Aminograpes/Interactive Preview

Aminograpes Model Preview

Zero-shot viral mutation fitness scoring with precomputed ProteinGym benchmark data

Reproduce & CodeResearch Paper
Select any viral target to inspect multi-model metrics and compute residue fitness
CPU Client-Side Engine
Virus / TargetHepatitis C Virus (HCV)NS5A Replication Complex
Structure BurialNo Structure (0.5)Plain alignment weight
Meta ESM2-650M0.116Spearman ρ
Aminograpes0.661+0.545 vs ESM2
Published Model Spearman Correlation on this Assay:
Aminograpes0.661
ESM2-650M0.116
ULB RSALOR0.629
Sorbonne GEMME0.630
PoET0.736
Site-Independent0.605
Conservation Only0.661
Mutation LookupFormula: Burial × Δlogf

Score Single or Multiple Mutations

Live Score OutputZero-shot computation

Mathematical Breakdown

Enter a mutation code above to view score breakdown.
Formula: ∑ [ Burial × (log f(mutant) - log f(wildtype)) ]

Predicted vs Experimental DMS Fitness Score

Assay: POLG_HCVJF_Qi_2014 (Hepatitis C Virus (HCV))

Assay score distribution for POLG_HCVJF_Qi_2014.

Published reference Spearman for this assay: 0.661.

Custom Protein Evaluation

Custom Protein Evaluation (Coming in v2)

Custom protein evaluation requires evolutionary sequence alignments and 3D structure generation, which involve dedicated GPU compute pipelines. We do not mock or simulate predictions.

Research Scope and Safety Notice
  • Aminograpes is a training-free zero-shot scoring model validated on viral assays only. Results on non-viral proteins are untested.
  • Accuracy depends on multiple sequence alignment depth and conservation profile quality.
  • Research use only. Not certified for clinical diagnostic, therapeutic prescribing, or biosecurity decisions.
  • Cite as: Structure-Weighted Evolutionary Scoring for Viral Protein Fitness Prediction (Aminograpes).